Anti-BAG2 Antibody Picoband®

Primary Antibodies

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

23772 MW

Western blot, 0.1-0.5?g/ml, Human, Rat, Mouse

BAG family molecular chaperone regulator 2

BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.

Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.

Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.

Apoptosis, Apoptotic Markers, Cancer, Cell Biology, Cell Death, Chaperones, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Pathways and Processes, Protein Trafficking, Signal Transduction

Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.

Boster Bio Anti-BAG2 Antibody catalog # PA2099. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.