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Anti-Cyclophilin B/PPIB Antibody Picoband® Europäischer Partner

ArtNr BOS-PA2151
Hersteller Boster
Menge 100 ug/vial
Kategorie
Typ Antibody Polyclonal
Format Lyophilized
Applikationen WB, IHC
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Sensitivity <10pg/ml
Citations 1. Barnes, A. M., Cabral, W. A., Weis, M., Makareeva, E., Mertz, E. L., Leikin, S., Eyre, D., Trujillo, C., Marini, J. C. Absence of FKBP10 in recessive type XI osteogenesis imperfecta leads to diminished collagen cross-linking and reduced collagen deposition in extracellular matrix. Hum. Mutat. 33: 1589-1598, 2012.
2. van Dijk, F. S., Cobben, J. M., Pals, G. Osteogenesis imperfecta, normal collagen folding, and lack of cyclophilin B. (Letter) New Eng. J. Med. 362: 1940-1941, 2010.
3. Watashi, K., Ishii, N., Hijikata, M., Inoue, D., Murata, T., Miyanari, Y., Shimotohno, K.Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase.Molec. Cell 19: 111-122, 2005.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Peptidyl-prolyl cis-trans isomerase B;PPIase B;5.2.1.8;CYP-S1;Cyclophilin B;Rotamase B;S-cyclophilin;SCYLP;PPIB;CYPB;
Similar products AA408962 antibody, AA553318 antibody, AI844835 antibody, Cphn 2 antibody, Cphn2 antibody, Cyclophilin B antibody, Cyclophilin like protein antibody, CyP 20b antibody, CYP S1 antibody, CYP-S1 antibody, CYPB antibody, EC 5.2.1.8 antibody, MGC14109 antibody, MGC2224 antibody, OI9 antibody, peptidyl prolyl cis trans isomerase B antibody, Peptidyl prolyl cis trans isomerase B precursor antibody, Peptidyl-prolyl cis-trans isomerase B antibody, Peptidyl-prolyl cis-trans isomerase B precursor antibody, peptidylprolyl isomerase B(cyclophilin B) antibody, Peptidylprolyl isomerase B antibody, PPIase antibody, PPIase B antibody, PPIB antibody, PPIB_HUMAN antibody, Rotamase antibody, Rotamase B antibody, S cyclophilin antibody, S-cyclophilin antibody, SCYLP antibody
Lieferbar
Manufacturer - Category
Primary Antibodies
Manufacturer - Isotype
Rabbit IgG
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
18 kDa
Calculated Molecular weight
23743 MW
Clonality
Polyclonal
Application Details
Western blot, 0.1-0.5?g/ml, Human, Mouse, Rat

Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml, Human, Mouse, By Heat
Manufacturer - Gene Name
PPIB
Gene Full Name
Peptidyl-prolyl cis-trans isomerase B
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
Peptidyl-prolyl cis-trans isomerase B, also known as CYPB, is an enzyme that in humans is encoded by the PPIB gene. This gene is mapped to 15q22.31. The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human Cyclophilin B, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
Contents
Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.01mg NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category
ER Proteins, Immunology, Protein Trafficking, Signal Transduction
Protein Name
Peptidyl-prolyl cis-trans isomerase B
Protein Function
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
Subcellular Localization
Endoplasmic reticulum lumen. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Description
Boster Bio Anti-Cyclophilin B/PPIB Antibody catalog # PA2151. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Sequence Similarities
Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug/vial
Lieferbar: In stock
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