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Anti-E3 SUMO-protein ligase PIAS4 Antibody

Anti-E3 SUMO-protein ligase PIAS4 Antibody

Hersteller	Boster
Kategorie	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Neural Transcription Factors Molecular Targets for Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Carcinoma Obesity Western Blot Enzymes Fatty Acid Synthesis Primary Antibodies By Organ Colorectal Cancer Glial Cell Markers
Typ	Antibody Polyclonal
Specific against	Human, Mouse, Rat
Isotype	IgG
Format	Lyophilized
Applikationen	WB
Menge	100 ug/vial
Host	Rabbit
ArtNr	BOS-PA2215
Targets	SOAT1
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	Chromatin Binding Proteins, Chromatin Modifying Enzymes, Co-Factors, DNA/RNA Binding, Epigenetics and Nuclear Signaling, Nuclear Signaling Pathways, Transcription, Ubiquitin & Ubiquitin Like Modifiers
Short Description	Boster Bio Anti-E3 SUMO-protein ligase PIAS4 Antibody catalog # PA2215. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-E3 SUMO-protein ligase PIAS4 Antibody catalog # PA2215. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Background	E3 SUMO-protein ligase PIAS4, also known as protein inhibitor of activated STAT protein 4 (PIAS4) or protein inhibitor of activated STAT protein gamma (PIASg or PIASy) is an enzyme that in humans is encoded by the PIAS4 gene. This gene is mapped to 19p13.3. This gene plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. It functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This gene involved in gene silencing.
Gene Name	PIAS4
Application Details	Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat
Application Notes	Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
Predicted Reactivity	Hamster
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human PIAS4, identical to the related mouse and rat sequences.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	E3 SUMO-protein ligase PIAS4
Molecular Weight	56504 MW
Protein Function	Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation..
Subcellular Localization	Nucleus, PML body. Colocalizes with SUMO1 and TCF7L2/TCF4 and LEF1 in a subset of PML (promyelocytic leukemia) nuclear bodies.
Tissue Specificity	Highly expressed in testis and, at lower levels, in spleen, prostate, ovary, colon and peripheral blood leukocytes..
Protein Name	E3 SUMO-protein ligase PIAS4
Sequence Similarities	Belongs to the PIAS family.

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