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Anti-Otx2 Antibody Picoband™

Anti-Otx2 Antibody Picoband™

Hersteller	Boster
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Blastoma Western Blot Primary Antibodies By Organ Colorectal Cancer S100 Calcium Binding Protein B Markers Macrophage Markers
Typ	Antibody Polyclonal
Specific against	Human
Isotype	IgG
Format	Lyophilized
Applikationen	WB
Menge	100 ug/vial
Host	Rabbit
ArtNr	BOS-PB9344
Targets	OTX2
eClass 6.1	32160702
eClass 9.0	32160702
Lieferbar
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	Developmental Biology, Embryogenesis, Epigenetics and Nuclear Signaling, Lineage Markers, Lineage Specification, Nervous System Development, Neurogenesis, Neurology Process, Neuroscience, Organogenesis, Sensory System, Stem Cells, Transcription, Visual System
Short Description	Boster Bio Anti-Otx2 Antibody Picoband™ catalog # PB9344. Tested in WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-Otx2 Antibody Picoband™ catalog # PB9344. Tested in WB applications. This antibody reacts with Human.
Background	OTX2 is also known as CPHD6 or MCOPS5. This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine.
Gene Name	OTX2
Application Details	Western blot, 0.1-0.5μg/ml, Human
Application Notes	WB: The detection limit for Otx2 is approximately 0.1ng/lane under reducing conditions. Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
Predicted Reactivity	Hamster
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human Otx2, identical to the related mouse sequence.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	Homeobox protein OTX2
Molecular Weight	31636 MW
Protein Function	Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
Subcellular Localization	Nucleus.
Tissue Specificity	Expressed in brain.
Protein Name	Homeobox protein OTX2
Sequence Similarities	Belongs to the paired homeobox family. Bicoid subfamily.

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