Anti-a-Synuclein (Ab-133) SNCA Antibody

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Predicted MW: 18kd

Western blotting: 1:500~1:1000

Immunofluorescence: 1:100~1:200

May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Kozikowski AP, et al. (2006)ChemMedChem. 1(2):256-66.
Jakowec MW, et al.(2001)Dev Neurosci.23(2):91-9.
El-Agnaf OM, et al.(1998)FEBS Lett. 440(1-2):67-70.

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1 mg/ml

Boster Bio Anti-a-Synuclein (Ab-133) SNCA Antibody (Catalog # A00215-2). Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.