Antibodies

Anti-Lipocalin 2 Antibody

Hersteller Boster
Kategorie
Typ Antibody Polyclonal
Specific against other
Isotype IgG
Format Lyophilized
Applikationen ELISA
Menge 100ug/vial
Host Rabbit
ArtNr BOS-A00452
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Reactivity
Reacts with: mouse
Description short
Rabbit IgG polyclonal antibody for Lipocalin 2 detection. Tested with ELISA(Cap) in Mouse.
Specificity
No cross reactivity with other proteins.
Application details
ELISA(Cap)|2-8μ g/ml
Notes
Tested Species: In-house tested species with positive results.
Other applications have not been tested.
Optimal dilutions should be determined by end users.
Immunogen
E. coli-derived mouse Lipocalin 2 recombinant protein (Position: Q21-N200).
Contents
Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Storage
At -20C for one year. After reconstitution, at 4C for one month. It can also be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing.
Background
Europhile gelatinase-associated lipocalin (NGAL) is a protein that in humans is encoded by the LCN2 gene. The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor.
Reference
1. Cowland JB, Borregaard N (October 1997). "Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans". Genomics 45 (1): 17–23.
2. Chan P, Simon-Chazottes D, Mattei MG, Guenet JL, Salier JP (September 1994). "Comparative mapping of lipocalin genes in human and mouse: the four genes for complement C8 gamma chain, prostaglandin-D-synthase, oncogene-24p3, and progestagen-associated endometrial protein map to HSA9 and MMU2". Genomics 23 (1): 145–50.
3. Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A (December 2004). "Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron". Nature 432 (7019): 917–21.
4. Kjeldsen L, Johnsen AH, Sengeløv H, Borregaard N (May 1993). "Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase". J. Biol. Chem. 268 (14): 10425–32.
5. Nelson AM, Zhao W, Gilliland KL, Zaenglein AL, Liu W, Thiboutot DM (April 2008).
6. Schmidt-Ott KM, Mori K, Li JY, Kalandadze A, Cohen DJ, Devarajan P, Barasch J (February 2007). "Dual action of neutrophil gelatinase-associated lipocalin". J. Am. Soc. Nephrol. 18 (2): 407–13.
Gene Name
Lcn2
Protein Name
Neutrophil gelatinase-associated lipocalin
Gene Full Name
lipocalin 2
Uniprot ID
P11672
Entrez GeneID
16819

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Menge: 100ug/vial
Lieferbar: In stock
Listenpreis: 240,00 €
Preis: 240,00 €
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