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Anti-MLTK MAP3K20 Antibody

Anti-MLTK MAP3K20 Antibody

ArtNr	BOS-A00902
Hersteller	Boster
Menge	100 ul
Kategorie	Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies Glial Cell Markers
Typ	Antibody
Format	Liquid
Applikationen	WB, IF
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Mitogen-activated protein kinase kinase kinase MLT;2.7.11.25;Human cervical cancer suppressor gene 4 protein;HCCS-4;Leucine zipper- and sterile alpha motif-containing kinase;MLK-like mitogen-activated protein triple kinase;Mixed lineage kinase-related kinase;MLK-related kinase;MRK;Sterile alpha motif- and leucine zipper-containing kinase AZK;ZAK;MLTK;HCCS4;
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Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	91155 MW
Clonality	Polyclonal
Application Details	Western blotting: 1:500~1:3000 Immunofluorescence: 1:100~1:500
Manufacturer - Gene Name	MAP3K20
Gene Full Name	Mitogen-activated protein kinase kinase kinase MLT
Background	Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'. Gotoh I., J. Biol. Chem. 276:4276-4286(2001). Bloem L.J., J. Mol. Cell. Cardiol. 33:1739-1750(2001). Gross E.A., J. Biol. Chem. 277:13873-13882(2002).
Immunogen	Synthesized peptide derived from C-terminal of human MLTK.
Contents	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration	1 mg/ml
Protein Function	Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636).
Subcellular Localization	Cytoplasm. Nucleus. Translocates to the nucleus upon ultraviolet B irradiation.
Short Description	Boster Bio Anti-MLTK MAP3K20 Antibody (Catalog # A00902). Tested in WB, IF applications. This antibody reacts with Human, Mouse.
Description	Boster Bio Anti-MLTK MAP3K20 Antibody (Catalog # A00902). Tested in WB, IF applications. This antibody reacts with Human, Mouse.
Tissue Specificity	Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.

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BOS-A00902-datasheet.pdf

BOS-A00902-safety-datasheet.pdf