Anti-TRBP Antibody

Hersteller Boster
Kategorie
Typ Antibody
Specific against other
Applikationen WB
Menge 100 ug
Host Rabbit
ArtNr BOS-A01680
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Gene name
TARBP2
Clonality
Polyclonal
Conjugate
No
Contents
100 ug in 200 ul PBS containing 0.05% BSA and 0.05% sodium azide.
Description
Polyclonal antibody for TARBP2 detection. Host: Rabbit.Size: 100 ug. Tested applications: WB. Reactive species: Human. TARBP2 information: Molecular Weight: 39039 MW; Subcellular Localization: Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
Uniprot ID
Q15633
Immunogen
A partial length recombinant TRBP protein (amino acids 150-366).
Storage
Store the antibody at 4° C, stable for 6 months. For long-term storage, store at -20° C. Avoid repeated freeze and thaw cycles.
Application details
Western blot analysis, 6-7 ug/ml
Reactivity
Human
Research category
TARBP2
Synonyms
RISC-loading complex subunit TARBP2 , TAR RNA-binding protein 2, Trans-activation-responsive RNA-binding protein, TARBP2 , TRBP,
Molecular weight
39039 MW
Protein function
Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR. .
Menge: 100 ug
Lieferbar: In stock
Listenpreis: 386,89 €
Preis: 386,89 €
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