Anti-Ezrin Antibody

ArtNr	BOS-A01750
Hersteller	Boster
Menge	100 ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Carcinoma Adenocarcinoma Immunohistochemistry Western Blot Primary Antibodies Microglia Markers
Typ	Antibody
Format	Liquid
Applikationen	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Ezrin;Cytovillin;Villin-2;p81;EZR;VIL2;
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	69413 MW
Clonality	Polyclonal
Application Details	Western blotting: 1:500~1:3000 Immunohistochemistry: 1:50~1:100
Manufacturer - Gene Name	EZR
Gene Full Name	Ezrin
Background	Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. Lixin Zhu, Am J Physiol Cell Physiol, Jun 2005; 288: C1242 - C1254. H.J. Spence, Hum. Mol. Genet., Aug 2004; 13: 1657 - 1668. Vera L¨²cia Bonilha, J. Cell Biol., Dec 1999; 147: 1533. M Berryman, J. Cell Biol., Dec 1995; 131: 1231.
Immunogen	Synthesized peptide derived from human Ezrin.
Contents	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration	1 mg/ml
Manufacturer - Research Category	Actin Binding Proteins, Actin, etc., Adapters, Cancer, Cytoplasmic, Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Protein Phosphorylation, Signal Transduction
Protein Function	Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
Subcellular Localization	Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Localization to the apical membrane of parietal cells depends on the interaction with MPP5. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side).
Short Description	Boster Bio Anti-Ezrin Antibody (Catalog # A01750). Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-Ezrin Antibody (Catalog # A01750). Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed in cerebral cortex, basal ganglia, hippocampus, hypophysis, and optic nerve. Weakly expressed in brain stem and diencephalon. Stronger expression was detected in gray matter of frontal lobe compared to white matter (at protein level). Component of the microvilli of intestinal epithelial cells. Preferentially expressed in astrocytes of hippocampus, frontal cortex, thalamus, parahippocampal cortex, amygdala, insula, and corpus callosum. Not detected in neurons in most tissues studied.

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