Hersteller |
Boster
|
Kategorie |
|
Typ |
Antibody Primary |
Specific against |
Human |
Isotype |
IgG |
Format |
Liquid |
Applikationen |
FC |
Menge |
100 ug/vial |
Host |
Rabbit |
ArtNr |
BOS-A01756-Dyl488 |
Konjugat/Tag |
DyLight 488 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies, Rabbit Polyclonal Antibodies |
Manufacturers Research Category |
Actin Binding Proteins, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Organelle Proteins, Protein Trafficking, Signal Transduction |
Short Description |
Boster Bio Anti-Human CD2AP DyLight® 488 conjugated Antibody catalog # A01756-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-Human CD2AP DyLight® 488 conjugated Antibody catalog # A01756-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human. |
Background |
CD2-associated protein is a protein that in humans is encoded by the CD2AP gene. This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease. |
Gene Name |
CD2AP |
Application Details |
Flow Cytometry, 1-3μg/1x106 cells |
Clonality |
Polyclonal |
Concentration |
0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure. |
Contents |
Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3. |
Immunogen |
E. coli-derived human CD2AP recombinant protein (Position: K253-K337). |
Cross-reactivity |
No cross-reactivity with other proteins. |
Storage |
At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light. |
Gene Full Name |
CD2 associated protein |
Protein Function |
Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. |
Subcellular Localization |
Cytoplasm, cytoskeleton. Cell projection, ruffle. Colocalizes with F-actin and BCAR1/p130Cas in membrane ruffles. Located at podocyte slit diaphragm between podocyte foot processes (By similarity). During late anaphase and telophase, concentrates in the vicinity of the midzone microtubules and in the midbody in late telophase. |
Tissue Specificity |
Widely expressed in fetal and adult tissues. |
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