Anti-Human CD2AP DyLight® 488 conjugated Antibody

Primary Antibodies, Rabbit Polyclonal Antibodies

Boster Bio Anti-Human CD2AP DyLight® 488 conjugated Antibody catalog # A01756-Dyl488. Tested in Flow Cytometry applications. This antibody reacts with Human.

CD2-associated protein is a protein that in humans is encoded by the CD2AP gene. This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.

Flow Cytometry, 1-3μg/1x10⁶ cells

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

E. coli-derived human CD2AP recombinant protein (Position: K253-K337).

At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T- cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis.

Widely expressed in fetal and adult tissues.