Anti-MADD Antibody

ArtNr	BOS-A02030
Hersteller	Boster
Menge	100 ul
Kategorie	Neuroscience Metabolism Diabetes Glucose Homeostasis Neural Signaling Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies
Typ	Antibody
Format	Liquid
Applikationen	WB, IF, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	MAP kinase-activating death domain protein;Differentially expressed in normal and neoplastic cells;Insulinoma glucagonoma clone 20;Rab3 GDP/GTP exchange factor;MADD ;DENN , IG20 , KIAA0358 ;
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	183303 MW
Clonality	Polyclonal
Application Details	Western blotting: 1:500~1:3000 Immunohistochemistry: 1:50~1:100 Immunofluorescence: 1:100~1:500
Manufacturer - Gene Name	MADD
Gene Full Name	MAP kinase-activating death domain protein
Background	Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect. Chow V.T.K., DNA Seq. 6:263-273(1996). Schievella A.R., J. Biol. Chem. 272:12069-12075(1997). Chow V.T.K., Genome 41:543-552(1998).
Immunogen	Synthesized peptide derived from internal of human MADD.
Contents	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration	1 mg/ml
Protein Function	Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Isoform 5 shows increased cell proliferation and isoform 2 shows decreased. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis); isoform 1 is susceptible to inducing apoptosis, isoform 5 is resistant and isoform 3 and isoform 4 have no effect.
Subcellular Localization	Membrane. Cytoplasm.
Short Description	Boster Bio Anti-MADD Antibody (Catalog # A02030). Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-MADD Antibody (Catalog # A02030). Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Highly expressed in fetal brain and kidney; adult testis, ovary, brain and heart. Isoform 5 is constitutively expressed in all tissues. Isoform 7 is expressed in fetal liver and in several cancer cell lines.

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