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Anti-Doppel/PRND Antibody Picoband™

Anti-Doppel/PRND Antibody Picoband™

ArtNr	BOS-A05457
Hersteller	Boster
Menge	100 ug/vial
Quantity options	100 ug/vial 10 ug
Kategorie	Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Primary
Format	Lyophilized
Applikationen	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Citations	1. Comincini, S., Foti, M. G., Tranulis, M. A., Hills, D., Di Guardo, G., Vaccari, G., Williams, J. L., Harbitz, I., Ferretti, L. Genomic organization, comparative analysis, and genetic polymorphisms of the bovine and ovine prion Doppel genes (PRND). Mammalian Genome 12: 729-733, 2001. 2. Croes, E. A., Alizadeh, B. Z., Bertoli-Avella, A. M., Rademaker, T., Vergeer-Drop, J., Dermaut, B., Houwing-Duistermaat, J. J., Wientjens, D. P. W. M., Hofman, A., Van Broeckhoven, C., van Duijn, C. M. Polymorphisms in the prion protein gene and in the doppel gene increase susceptibility for Creutzfeldt-Jakob disease. Europ. J. Hum. Genet. 12: 389-394, 2004. 3. Genoud, N., Behrens, A., Miele, G., Robay, D., Heppner, F. L., Freigang, S., Aguzzi, A.Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions.Proc. Nat. Acad. Sci. 101: 4198-4203, 2004.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Manufacturer - Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Storage Conditions	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Molecular Weight	23 kDa
Clonality	Polyclonal
Application Details	Western blot, 0.1-0.5μg/ml Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml
Gene Name	PRND
Gene Full Name	Germinal-center associated nuclear protein
Background	Prion protein 2 (dublet), also known as PRND, or Doppel protein, is a protein which in humans is encoded by the PRND gene. It is mapped to 20p13. This gene is found on chromosome 20, approximately 20 kbp downstream of the gene encoding cellular prion protein, to which it is biochemically and structurally similar. The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that is found predominantly in testis. Mutations in this gene may lead to neurological disorders.
Contents	Each vial contains 4 mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄, 0.05 mg NaN₃.
Reconstitution	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category	Neurodegenerative Disease, Neurology Process, Neuroscience
Protein Function	Required for normal acrosome reaction and for normal male fertility (By similarity). Can bind Cu (2+) (PubMed:15218028, PubMed:20411530).
Tissue Specificity	Expressed in testis, in Sertoli cells, ejaculated spermatozoa and in seminal fluid (at protein level).

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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BOS-A05457-datasheet.pdf

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