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Anti-Cytochrome P450 4F11 CYP4F11 Antibody

Anti-Cytochrome P450 4F11 CYP4F11 Antibody

ArtNr	BOS-A09078
Hersteller	Boster
Menge	100 ul
Kategorie	Food Safety Drugs Antibodies Western Blot Primary Antibodies
Typ	Antibody
Format	Liquid
Applikationen	WB
Specific against	Human (Homo sapiens)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Phylloquinone omega-hydroxylase CYP4F11 ;1.14.13.194 ;3-hydroxy fatty acids omega-hydroxylase CYP4F11 ;1.14.13.- ;Cytochrome P450 4F11;CYPIVF11;CYP4F11 ;
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Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	60146 MW
Clonality	Polyclonal
Application Details	Western blotting: 1:500~1:3000
Manufacturer - Gene Name	CYP4F11
Gene Full Name	Phylloquinone omega-hydroxylase CYP4F11
Background	A member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. Cui X., Genomics 68:161-166(2000). Grimwood J., Nature 428:529-535(2004). The MGC Project Team, Genome Res. 14:2121-2127(2004).
Immunogen	Synthesized peptide derived from internal of human Cytochrome P450 4F11.
Contents	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration	1 mg/ml
Protein Function	Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:24138531). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids, such as 3-hydroxypalmitate, 3-hydroxyoleate, 3- hydroxyarachidonate, and 3-hydroxystearate (PubMed:18065749, PubMed:19932081). Oxidizes drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine and imipramine (PubMed:15364545).
Subcellular Localization	Microsome membrane; Single-pass membrane protein.
Short Description	Boster Bio Anti-Cytochrome P450 4F11 CYP4F11 Antibody (Catalog # A09078). Tested in WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-Cytochrome P450 4F11 CYP4F11 Antibody (Catalog # A09078). Tested in WB applications. This antibody reacts with Human.
Tissue Specificity	Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle.

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BOS-A09078-datasheet.pdf

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