Hersteller |
Boster
|
Kategorie |
|
Typ |
Antibody |
Specific against |
Human |
Format |
Liquid |
Applikationen |
WB |
Menge |
100ul |
Host |
Rabbit |
ArtNr |
BOS-A09078 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Manufacturers Product Category |
Primary Antibodies |
Short Description |
Boster Bio Anti-Cytochrome P450 4F11 CYP4F11 Antibody (Catalog # A09078). Tested in WB applications. This antibody reacts with Human. |
Description |
Boster Bio Anti-Cytochrome P450 4F11 CYP4F11 Antibody (Catalog # A09078). Tested in WB applications. This antibody reacts with Human. |
Background |
A member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
Cui X., Genomics 68:161-166(2000). Grimwood J., Nature 428:529-535(2004). The MGC Project Team, Genome Res. 14:2121-2127(2004). |
Gene Name |
CYP4F11 |
Clonality |
Polyclonal |
Concentration |
1 mg/ml |
Contents |
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Application Details |
Western blotting: 1:500~1:3000 |
Immunogen |
Synthesized peptide derived from internal of human Cytochrome P450 4F11. |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Storage |
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles. |
Gene Full Name |
Phylloquinone omega-hydroxylase CYP4F11 |
Molecular Weight |
60146 MW |
Protein Function |
Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:24138531). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids, such as 3-hydroxypalmitate, 3-hydroxyoleate, 3- hydroxyarachidonate, and 3-hydroxystearate (PubMed:18065749, PubMed:19932081). Oxidizes drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine and imipramine (PubMed:15364545).. |
Subcellular Localization |
Microsome membrane ; Single-pass membrane protein. |
Tissue Specificity |
Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle.. |
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