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Anti-Cytochrome P450 4F11 CYP4F11 Antibody

Hersteller Boster
Kategorie
Typ Antibody
Specific against Human
Format Liquid
Applikationen WB
Menge 100ul
Host Rabbit
ArtNr BOS-A09078
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Manufacturers Product Category
Primary Antibodies
Short Description
Boster Bio Anti-Cytochrome P450 4F11 CYP4F11 Antibody (Catalog # A09078). Tested in WB applications. This antibody reacts with Human.
Description
Boster Bio Anti-Cytochrome P450 4F11 CYP4F11 Antibody (Catalog # A09078). Tested in WB applications. This antibody reacts with Human.
Background
A member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Cui X., Genomics 68:161-166(2000).
Grimwood J., Nature 428:529-535(2004).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Gene Name
CYP4F11
Clonality
Polyclonal
Concentration
1 mg/ml
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Application Details
Western blotting: 1:500~1:3000
Immunogen
Synthesized peptide derived from internal of human Cytochrome P450 4F11.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Gene Full Name
Phylloquinone omega-hydroxylase CYP4F11
Molecular Weight
60146 MW
Protein Function
Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:24138531). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids, such as 3-hydroxypalmitate, 3-hydroxyoleate, 3- hydroxyarachidonate, and 3-hydroxystearate (PubMed:18065749, PubMed:19932081). Oxidizes drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine and imipramine (PubMed:15364545)..
Subcellular Localization
Microsome membrane ; Single-pass membrane protein.
Tissue Specificity
Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle..

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100ul
Lieferbar: In stock
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Lieferung vsl. bis 02.05.2024 

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