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Anti-Cytochrome P450 4F11 CYP4F11 Antibody

Anti-Cytochrome P450 4F11 CYP4F11 Antibody

Manufacturer	Boster
Category	Food Safety Drugs Antibodies Western Blot Primary Antibodies
Type	Antibody
Specific against	Human
Format	Liquid
Applications	WB
Amount	100ul
Host	Rabbit
Item no.	BOS-A09078
eClass 6.1	32160702
eClass 9.0	32160702
Available
Manufacturers Product Category	Primary Antibodies
Short Description	Boster Bio Anti-Cytochrome P450 4F11 CYP4F11 Antibody (Catalog # A09078). Tested in WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-Cytochrome P450 4F11 CYP4F11 Antibody (Catalog # A09078). Tested in WB applications. This antibody reacts with Human.
Background	A member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F2, is approximately 16 kb away. Alternatively spliced transcript variants encoding the same protein have been found for this gene. Cui X., Genomics 68:161-166(2000). Grimwood J., Nature 428:529-535(2004). The MGC Project Team, Genome Res. 14:2121-2127(2004).
Gene Name	CYP4F11
Clonality	Polyclonal
Concentration	1 mg/ml
Contents	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Application Details	Western blotting: 1:500~1:3000
Immunogen	Synthesized peptide derived from internal of human Cytochrome P450 4F11.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Gene Full Name	Phylloquinone omega-hydroxylase CYP4F11
Molecular Weight	60146 MW
Protein Function	Omega-hydroxylase that oxidizes a variety of structurally unrelated compounds, including fatty acids and xenobiotics. Plays a key role in vitamin K catabolism by mediating omega-hydroxylation of vitamin K1 (phylloquinone), and menaquinone-4 (MK-4), a form of vitamin K2. Hydroxylation of phylloquinone and MK-4 probably regulates blood coagulation (PubMed:24138531). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids, such as 3-hydroxypalmitate, 3-hydroxyoleate, 3- hydroxyarachidonate, and 3-hydroxystearate (PubMed:18065749, PubMed:19932081). Oxidizes drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine and imipramine (PubMed:15364545)..
Subcellular Localization	Microsome membrane ; Single-pass membrane protein.
Tissue Specificity	Expressed mainly in human liver, followed by kidney, heart, and skeletal muscle..

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Amount: 100ul

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Delivery expected until 5/30/2024