Anti-MAP4K6 MINK1 Antibody

ArtNr	BOS-A30524
Hersteller	Boster
Menge	100 ul
Kategorie	Neuroscience Neural Lineage Markers Metabolism Diabetes Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Antibodies Western Blot Primary Antibodies Glial Cell Markers Astrocyte Markers
Typ	Antibody
Format	Liquid
Applikationen	WB, IF, ELISA, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	MINK1;B55;MAP4K6;MINK;YSK2;ZC3;Misshapen-like kinase 1;GCK family kinase MiNK;MAPK/ERK kinase kinase kinase 6;MEK kinase kinase 6;MEKKK 6;Misshapen/NIK-related kinase;Mitogen-activated protein kinase kinase kinase kinase 6
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Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	149822 MW
Clonality	Polyclonal
Application Details	Western Blot, 1:500 - 1:2000 Immunohistochemistry, 1:100 - 1:300 ELISA, 1:20000 Not yet tested in other applications.
Manufacturer - Gene Name	MINK1
Gene Full Name	Misshapen-like kinase 1
Immunogen	A peptide derived from human MAP4K6. Immunogen sequence location: 401-450
Contents	PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	MAPK Pathway, Neural Signal Transduction, Neurology Process, Neuroscience, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction
Protein Function	Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1.
Subcellular Localization	Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, axon. Cell projection, dendrite.
Short Description	Boster Bio Anti-MAP4K6 MINK1 Antibody (Catalog# A30524). Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Mouse.
Description	Boster Bio Anti-MAP4K6 MINK1 Antibody (Catalog# A30524). Tested in WB, IHC-P, IF (paraffin), ELISA applications. This antibody reacts with Human, Mouse.
Tissue Specificity	Expressed in the brain, isoform 2 is more abundant than isoform 1. Isoform 3 is ubiquitously expressed. Isoform 1 is most abundant in the skeletal muscle. Isoform 4 is ubiquitously expressed with relative high levels in brain, skeletal muscle, pancreas and testis.

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BOS-A30524-datasheet.pdf

BOS-A30524-safety-datasheet.pdf