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Anti-human CD33/Siglec 3 Monoclonal Antibody Biotin Conjugated, Flow Validated

Anti-human CD33/Siglec 3 Monoclonal Antibody Biotin Conjugated, Flow Validated

ArtNr	BOS-FC01508-Biotin
Hersteller	Boster
Menge	100 ug
Kategorie	Neuroscience Neuroinflammation Antibodies Flow Cytometry Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	FC
Clon	WM53
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Konjugat/Tag	Biotin
Sensitivity	5ul per sample
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Myeloid cell surface antigen CD33;Sialic acid-binding Ig-like lectin 3;Siglec-3;gp67;CD33;CD33;SIGLEC3;
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Manufacturer - Category	Monoclonal Antibodies, Primary Antibodies
Storage Conditions	Store at 2-8°C. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	39825 MW
Clonality	Monoclonal
Application Details	User needs to optimize the dilution ratio for this antibody.
Manufacturer - Gene Name	CD33
Gene Full Name	Myeloid cell surface antigen CD33
Background	CD33, also known as Siglec-3 (sialic acid binding Ig-like lectin 3, SIGLEC3, SIGLEC-3, gp67, p67), is a transmembrane receptor expressed on cells of myeloid lineage. It is usually considered myeloid-specific, but it can also be found on some lymphoid cells. CD33 binds sialic acids, therefore is a member of the SIGLEC family of lectins. By fluorescence in situ hybridization, CD33 is mapped to 19q13.3-q13.4.
Immunogen	Human AML cells
Contents	PBS pH 7.2, 0.09% sodium azide
Purification	Protein A purified
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Cell Type Markers, Hematopoietic Progenitors, Immunology, Stem Cells
Protein Name	Myeloid cell surface antigen CD33
Protein Function	Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2, 6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
Subcellular Localization	Cell membrane; Single-pass type I membrane protein.
Short Description	Boster Bio Anti-human CD33/Siglec 3 Monoclonal Antibody Biotin Conjugated, Flow Validated (Catalog# FC01508-Biotin). Tested in Flow Cytometry application(s). This antibody reacts with Human.
Description	Boster Bio Anti-human CD33/Siglec 3 Monoclonal Antibody Biotin Conjugated, Flow Validated (Catalog# FC01508-Biotin). Tested in Flow Cytometry application(s). This antibody reacts with Human.
Tissue Specificity	Monocytic/myeloid lineage cells.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

BOS-FC01508-Biotin-datasheet.pdf

BOS-FC01508-Biotin-safety-datasheet.pdf