Anti-Sonic Hedgehog SHH Rabbit Monoclonal Antibody

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

49607 MW

WB 1:500-2000
IHC 1:50-200
ICC/IF 1:50-200
FC 1:50

Sonic hedgehog protein

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Cancer, Cancer Metabolism, Developmental Biology, Developmental Families, Domain Families, Embryogenesis, Embryonic Stem Cells, Epigenetics and Nuclear Signaling, Hypoxia, Intracellular, Metabolism, Metabolism Processes, Neural Stem Cells, Oncoproteins/Suppressors, Organogenesis, Pathways and Processes, Response To Hypoxia, Secreted, Signaling Pathways, Stem Cells, Surface Molecules, Transcription, Tumor Suppressors

Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity).

Boster Bio Anti-Sonic Hedgehog SHH Rabbit Monoclonal Antibody catalog # M00058. Tested in WB, IHC, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.