Anti-SP1 Rabbit Monoclonal Antibody

Rabbit Monoclonal Antibodies

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

80693 MW

WB 1:500-1:2000
IHC 1:50-1:200
ICC/IF 1:50-1:200

Transcription factor Sp1

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5 mg/ml BSA.

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

2339, Domain Families, Epigenetics and Nuclear Signaling, Metabolic Signaling Pathways, Metabolism, Mitochondrial Metabolism, Nuclear, Nucleotide Metabolism, Pathways and Processes, Signaling Pathways, Stem Cells, TGF Beta, Transcription, Zinc Finger

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.

Boster Bio Anti-SP1 Rabbit Monoclonal Antibody catalog # M00110. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.