Anti-CD11b (integrin alpha-M) ITGAM Rabbit Monoclonal Antibody, Clone#RM290

Rabbit IgG

127179 MW

Immunohistochemistry (IHC): 1:100-1:200 dilution

WB: 1:200-1:500 dilution.

Integrin alpha-M

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity).

Boster Bio Anti-CD11b (integrin alpha-M) ITGAM Rabbit Monoclonal Antibody, Clone#RM290 (Catalog # M00144-2). Tested in IHC, WB applications. This antibody reacts with Human.

Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407).