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Anti-CD11b (integrin alpha-M) ITGAM Rabbit Monoclonal Antibody, Clone#RM290

Anti-CD11b (integrin alpha-M) ITGAM Rabbit Monoclonal Antibody, Clone#RM290

Item no.	BOS-M00144-2
Manufacturer	Boster
Amount	100 ul
Category	Neuroscience Neural Lineage Markers Aging & Neurological Disorders Neural Adhesion Molecules Antibodies Immunohistochemistry Western Blot Primary Antibodies Oligodendrocyte Markers
Type	Antibody Primary
Format	Liquid
Applications	WB, IHC
Clone	RM290
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Integrin alpha-M;CD11 antigen-like family member B;CR-3 alpha chain;Cell surface glycoprotein MAC-1 subunit alpha;Leukocyte adhesion receptor MO1;Neutrophil adherence receptor;CD11b;ITGAM;CD11B, CR3A;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, Rabbit Monoclonal Antibodies, 2279
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	127179 MW
Clonality	Monoclonal
Application Details	Immunohistochemistry (IHC): 1:100-1:200 dilution WB: 1:200-1:500 dilution.
Manufacturer - Gene Name	ITGAM
Gene Full Name	Integrin alpha-M
Immunogen	A peptide corresponding to the C-terminus of human CD11b (Integrin alpha-M)
Contents	50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification	Protein A affinity purified from an animal origin-free culture supernatant
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Cell Adhesion, Cell Type Marker, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Integrins, Lymphoid, Mesenchymal Stem Cells, Myeloid, Neuroscience, Signal Transduction, Stem Cells, T Lymphocytic Lineage
Protein Function	Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity).
Subcellular Localization	Cell membrane; Single-pass type I membrane protein. Membrane raft; Single-pass type I membrane protein.
Short Description	Boster Bio Anti-CD11b (integrin alpha-M) ITGAM Rabbit Monoclonal Antibody, Clone#RM290 (Catalog # M00144-2). Tested in IHC, WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-CD11b (integrin alpha-M) ITGAM Rabbit Monoclonal Antibody, Clone#RM290 (Catalog # M00144-2). Tested in IHC, WB applications. This antibody reacts with Human.
Tissue Specificity	Predominantly expressed in monocytes and granulocytes (PubMed:1346576). Expressed in neutrophils (at protein level) (PubMed:21193407).

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M00144-2-datasheet.pdf

BOS-M00144-2-safety-datasheet.pdf