Anti-Cyclin D1 (CCND1) Rabbit Monoclonal Antibody, Clone#RM241

Primary Antibodies, Monoclonal Antibodies, Rabbit Monoclonal Antibodies, 2279

Store at -20°C for one year. Avoid repeated freeze-thaw cycles.

Monoclonal

CCND1

A peptide corresponding to Cyclin D1

Protein A affinity purified from an animal origin-free culture supernatant

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G (1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G (1) phase. Hypophosphorylates RB1 in early G (1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.

Boster Bio Anti-Cyclin D1 (CCND1) Rabbit Monoclonal Antibody, Clone#RM241 (Catalog # M00149-3). Tested in IHC, WB applications. This antibody reacts with Human.

Bovine, Mouse, Rat