Anti-Caveolin-1 CAV1 Rabbit Monoclonal Antibody, Clone#RM325

Rabbit IgG

20472 MW

Immunohistochemistry (IHC): 1:500-1:1000 dilution

WB: 1:5, 000-1:40, 000 dilution.

Caveolin-1

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564).

Boster Bio Anti-Caveolin-1 CAV1 Rabbit Monoclonal Antibody, Clone#RM325 (Catalog # M00179-2). Tested in IHC, WB applications. This antibody reacts with Human.

Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.