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Anti-Caveolin-1 CAV1 Rabbit Monoclonal Antibody, Clone#RM325

Anti-Caveolin-1 CAV1 Rabbit Monoclonal Antibody, Clone#RM325

Item no.	BOS-M00179-2
Manufacturer	Boster
Amount	100 ul
Category	Neuroscience Metabolism Cholesterol & Lipid Metabolism Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot Lipid & Fatty Acid Transport Primary Antibodies
Type	Antibody Primary
Format	Liquid
Applications	WB, IHC
Clone	RM325
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Caveolin-1;CAV1;CAV;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, Rabbit Monoclonal Antibodies, 2279
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	20472 MW
Clonality	Monoclonal
Application Details	Immunohistochemistry (IHC): 1:500-1:1000 dilution WB: 1:5, 000-1:40, 000 dilution.
Manufacturer - Gene Name	CAV1
Gene Full Name	Caveolin-1
Immunogen	A peptide corresponding to the C-terminus of human Caveolin-1.
Contents	50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification	Protein A affinity purified from an animal origin-free culture supernatant
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Calcium Channels, Calcium Signaling, Cancer, Cancer Metabolism, Energy Transfer Pathways, Integration Of Energy, Integration Of Energy Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Neuroscience, Neurotransmission, Pathways and Processes, Signal Transduction, Signaling Pathway
Protein Function	May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564).
Subcellular Localization	Golgi apparatus membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Golgi apparatus, trans-Golgi network. Colocalized with DPP4 in membrane rafts. Potential hairpin- like structure in the membrane. Membrane protein of caveolae.
Short Description	Boster Bio Anti-Caveolin-1 CAV1 Rabbit Monoclonal Antibody, Clone#RM325 (Catalog # M00179-2). Tested in IHC, WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-Caveolin-1 CAV1 Rabbit Monoclonal Antibody, Clone#RM325 (Catalog # M00179-2). Tested in IHC, WB applications. This antibody reacts with Human.
Tissue Specificity	Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level). Expressed in the brain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M00179-2-datasheet.pdf

BOS-M00179-2-safety-datasheet.pdf