Anti-TRAF6 Rabbit Monoclonal Antibody

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

59573 MW

WB 1:500-1:2000
IHC 1:50-1:200
FC 1:50-1:200

TNF receptor-associated factor 6

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Apoptosis, Associated Proteins, Cancer, Cell Biology, Cell Death, Growth Factors, Growth Factors/Hormones, Immunology, Innate Immunity, Invasion/Microenvironment, NFKB Pathway, Nuclear Signaling, Receptors, Signal Transduction, Signaling Pathway, TLR Signaling

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c- Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

Boster Bio Anti-TRAF6 Rabbit Monoclonal Antibody catalog # M00185-1. Tested in WB, IHC, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.