Anti-c-Fos Rabbit Monoclonal Antibody, Clone#RM374

Rabbit IgG

40695 MW

Immunohistochemistry (IHC): 1:500-1:1000 dilution

WB: 1:1000-1:5000 dilution.

Proto-oncogene c-Fos

50% Glycerol/PBS with 1% BSA and 0.09% sodium azide

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

Boster Bio Anti-c-Fos Rabbit Monoclonal Antibody, Clone#RM374 (Catalog # M00297-5). Tested in IHC, WB applications. This antibody reacts with Human.