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Anti-c-Fos Rabbit Monoclonal Antibody, Clone#RM374

Anti-c-Fos Rabbit Monoclonal Antibody, Clone#RM374

Item no.	BOS-M00297-5
Manufacturer	Boster
Amount	100 ul
Category	Neuroscience Neural Lineage Markers Neural Transcription Factors Neural Signaling Antibodies Immunohistochemistry Western Blot Primary Antibodies Neuronal Cell Markers
Type	Antibody Primary
Format	Liquid
Applications	WB, IHC
Clone	RM374
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Proto-oncogene c-Fos;Cellular oncogene fos;G0/G1 switch regulatory protein 7;FOS;G0S7;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, Rabbit Monoclonal Antibodies, 2279
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	40695 MW
Clonality	Monoclonal
Application Details	Immunohistochemistry (IHC): 1:500-1:1000 dilution WB: 1:1000-1:5000 dilution.
Manufacturer - Gene Name	FOS
Gene Full Name	Proto-oncogene c-Fos
Immunogen	A peptide corresponding to N-terminus of human Proto-oncogene c-Fos
Contents	50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification	Protein A affinity purified from an animal origin-free culture supernatant
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Cancer, Cancer Susceptibility, Domain Families, Epigenetics and Nuclear Signaling, Hlh/Leucine Zipper, Oncoproteins, Oncoproteins/Suppressors, Proto-Oncogenes, Transcription, Transcription Factors
Protein Function	Nuclear phosphoprotein which forms a tight but non- covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD- binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.
Subcellular Localization	Nucleus. Endoplasmic reticulum. Cytoplasm, cytosol. In quiescent cells, present in very small amounts in the cytosol. Following induction of cell growth, first localizes to the endoplasmic reticulum and only later to the nucleus. Localization at the endoplasmic reticulum requires dephosphorylation at Tyr-10 and Tyr-30.
Short Description	Boster Bio Anti-c-Fos Rabbit Monoclonal Antibody, Clone#RM374 (Catalog # M00297-5). Tested in IHC, WB applications. This antibody reacts with Human.
Description	Boster Bio Anti-c-Fos Rabbit Monoclonal Antibody, Clone#RM374 (Catalog # M00297-5). Tested in IHC, WB applications. This antibody reacts with Human.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M00297-5-datasheet.pdf

BOS-M00297-5-safety-datasheet.pdf