Anti-ULK1/Atg1 Rabbit Monoclonal Antibody

Rabbit Monoclonal Antibodies

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

112631 MW

WB 1:500-1:2000
IHC 1:50-1:200
ICC/IF 1:50-1:200

Serine/threonine-protein kinase ULK1

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5 mg/ml BSA.

Restore with deionized water (or equivalent) for reconstitution volume of 1.0 mL

Cardiovascular, Metabolism, Mitochondrial Metabolism, Neurogenesis, Neurology Process, Neuroscience, Pathways and Processes, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).

Boster Bio Anti-ULK1/Atg1 Rabbit Monoclonal Antibody catalog # M00584. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.