Anti-TDP43 TARDBP Monoclonal Antibody

Primary Antibodies, Monoclonal Antibodies, 2279

44740 MW

WB: 1:5, 000. ICC/IF and IHC 1:1, 000

TAR DNA-binding protein 43

Purified antibody at 1mg/mL in 50% PBS, 50% glycerol plus 5mM NaN₃

DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.

Boster Bio Anti-TDP43 TARDBP Monoclonal Antibody catalog # M01001-1. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Bovine, Equine, Human, Mouse, Pig, Rat.

Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.