« Back
Home /
Anti-TDP43 TARDBP Monoclonal Antibody

Anti-TDP43 TARDBP Monoclonal Antibody

Item no.	BOS-M01001-1
Manufacturer	Boster
Amount	100 ul
Category	Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Protein Aggregation, Clearance & Misfolding Antibodies Immunohistochemistry Western Blot Immunofluorescence Immunocytochemistry Primary Antibodies
Type	Antibody Monoclonal
Applications	WB, IF, IHC, ICC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus), Horse (Equine), Pig (Porcine, Sus scrofa domesticus), Cattle (Bovine)
Host	Mouse
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	TAR DNA-binding protein 43;TDP-43;TARDBP;TDP43;
Available
Manufacturer - Category	Primary Antibodies, Monoclonal Antibodies, 2279
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	44740 MW
Clonality	Monoclonal
Application Details	WB: 1:5, 000. ICC/IF and IHC 1:1, 000
Manufacturer - Gene Name	TARDBP
Gene Full Name	TAR DNA-binding protein 43
Immunogen	Full length recombinant human TDP43 expressed in and purified from E. coli
Contents	Purified antibody at 1mg/mL in 50% PBS, 50% glycerol plus 5mM NaN₃
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Protein Function	DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.
Subcellular Localization	Nucleus. In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies.
Short Description	Boster Bio Anti-TDP43 TARDBP Monoclonal Antibody catalog # M01001-1. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Bovine, Equine, Human, Mouse, Pig, Rat.
Description	Boster Bio Anti-TDP43 TARDBP Monoclonal Antibody catalog # M01001-1. Tested in IF, IHC, ICC, WB applications. This antibody reacts with Bovine, Equine, Human, Mouse, Pig, Rat.
Tissue Specificity	Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-M01001-1-datasheet.pdf

BOS-M01001-1-safety-datasheet.pdf