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Anti-Endoglin / CD105 (Angiogenesis Marker) ENG Monoclonal Antibody Europäischer Partner

ArtNr BOS-M02997
Hersteller Boster
Menge 100 ug
Kategorie
Typ Antibody Monoclonal
Format Liquid
Applikationen WB, FC, IF
Clon ENG/1327
Specific against Human (Homo sapiens)
Host Mouse
Isotype IgG1 Kappa
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Alias Endoglin;CD105;ENG;END;
Lieferbar
Manufacturer - Category
Primary Antibodies, Monoclonal Antibodies
Storage Conditions
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Observed Molecular Weight
70578 MW
Clonality
Monoclonal
Application Details
Flow Cytometry (0.5-1ug/million cells in 0.1ml)
Immunofluorescence (1-2ug/ml)
Western Blot (1-2ug/ml for 60 minutes at RT)
Optimal dilution for a specific application should be determined.
Manufacturer - Gene Name
ENG
Gene Full Name
Endoglin
Background
CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.
Immunogen
Recombinant human Endoglin protein fragment (aa74-251) (exact sequence is proprietary)
Contents
Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Purification
200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G.
Concentration
Purified antibody with BSA and azide at 200ug/ml
Manufacturer - Research Category
Epigenetics and Nuclear Signaling, Neurogenesis, Neurology Process, Neuroscience, Transcription
Protein Function
Major glycoprotein of vascular endothelium. Involved in the regulation of angiogenesis. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as TGF-beta coreceptor and is involved in the TGF- beta/BMP signaling cascade. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGF-beta1 signaling through SMAD3.
Subcellular Localization
Cytoplasmic
Short Description
Boster Bio Anti-Endoglin / CD105 (Angiogenesis Marker) ENG Monoclonal Antibody (Catalog # M02997). Tested in Flow Cytometry, IF, WB applications. This antibody reacts with Human.
Description
Boster Bio Anti-Endoglin / CD105 (Angiogenesis Marker) ENG Monoclonal Antibody (Catalog # M02997). Tested in Flow Cytometry, IF, WB applications. This antibody reacts with Human.
Tissue Specificity
Endoglin is restricted to endothelial cells in all tissues except bone marrow.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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