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Anti-Desmin Antibody (Monoclonal, DE-U-10)

Anti-Desmin Antibody (Monoclonal, DE-U-10)

Hersteller	Boster
Kategorie	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Targets for Rodent Neurosciences Antibodies By Cell Type Blastoma Carcinoma Hematology Lymphoma Melanoma Sarcoma Cell Biology Cytoskeleton Immunohistochemistry Western Blot Primary Antibodies Intermediate filaments Neurodegeneration Markers;Research Area Microglia Markers
Typ	Antibody Monoclonal
Specific against	Human, Mouse, Rat, Rabbit
Clon	DE-U-10
Isotype	IgG1
Format	Lyophilized
Applikationen	WB, IHC
Menge	100 ug/vial
Host	Mouse
ArtNr	BOS-MA1036
Targets	SOX9, GFAP, DES
eClass 6.1	32160702
eClass 9.0	42030590
Lieferbar
Manufacturers Product Category	Primary Antibodies, Mouse Monoclonal Antibodies
Manufacturers Research Category	Complement, Immunology, Innate Immunity
Short Description	Boster Bio Anti-Desmin Antibody (Monoclonal, DE-U-10) catalog # MA1036. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rabbit, Rat.
Description	Boster Bio Anti-Desmin Antibody (Monoclonal, DE-U-10) catalog # MA1036. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rabbit, Rat.
Background	Desmin belongs to the type III family of intermediate filaments, a class of cytoskeletal elements. DES gene encodes desmin, a muscle-specific cytoskeletal protein found in smooth, cardiac, and heart muscles. Tidball (1992) found that desmin was codistributed with actin thin filaments within the cellular processes of myotendinous junctions in frog skeletal muscle. DES gene contains 9 exons and spans about 8.4 kb. By in situ hybridization, Viegas-Pequignot et al. (1989) localized the gene to 2q35. Desmin mutation responsible for idiopathic dilated cardiomyopathy.
Gene Name	DES
Application Details	Immunohistochemistry (Paraffin-embedded Section), 2-4μg/ml, Human, mouse, rat, rabbit, By Heat Western blot, 2μg/ml, Human, mouse, rat, rabbit
Application Notes	Other applications have not been tested. Optimal dilutions should be determined by end users.
Clonality	Monoclonal
Concentration	Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.
Contents	Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.
Immunogen	Desmin from pig stomach.
Purification	Ascites
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 1ml of PBS buffer will yield a concentration of 100ug/ml.
Gene Full Name	Desmin
Molecular Weight	53457 MW
Protein Function	Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures..
Subcellular Localization	Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm. Cell membrane, sarcolemma. Localizes in the intercalated disks which occur at the Z line of cardiomyocytes..
Protein Name	Desmin
Sequence Similarities	Belongs to the intermediate filament family.

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