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Anti-Phospho-Smad2 (S255) Rabbit Monoclonal Antibody

Anti-Phospho-Smad2 (S255) Rabbit Monoclonal Antibody

ArtNr	BOS-P00090
Hersteller	Boster
Menge	100 ul/vial
Quantity options	100 ul/vial 30 ul
Kategorie	Neuroscience Neural Lineage Markers Targets for Rodent Neurosciences Antibodies Immunohistochemistry Immunoprecipitation Western Blot Primary Antibodies Neurodegeneration Markers
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IP, IHC
Clon	HBE-19
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	>5000 cells
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Mothers against decapentaplegic homolog 2,MAD homolog 2,Mothers against DPP homolog 2,JV18-1,Mad-related protein 2,hMAD-2,SMAD family member 2,SMAD 2,Smad2,hSMAD2,SMAD2,MADH2,MADR2
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Manufacturer - Category	Primary Antibodies, Rabbit Monoclonal Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular weight	100 kDa
Calculated Molecular weight	52306 MW
Clonality	Monoclonal
Application Details	WB 1:1000-1:2000 IHC 1:50-1:200 IP 1:50
Gene Name	SMAD2
Gene Full Name	Mothers against decapentaplegic homolog 2
Immunogen	A synthesized peptide derived from human Smad2
Contents	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Purification	Affinity-chromatography
Concentration	0.5mg/ml
Manufacturer - Research Category	Cancer, Cytoplasmic, Epigenetics and Nuclear Signaling, Growth Factors, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Stem Cells, TGF Beta
Protein Function	Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Subcellular Localization	Cytoplasm. Nucleus. Cytoplasmic and nuclear in the absence of TGF-beta. On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4. On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1.
Description	Boster Bio Anti-Phospho-Smad2 (S255) Rabbit Monoclonal Antibody catalog # P00090. Tested in WB, IHC, IP applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.
Phospho Site	S255

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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BOS-P00090-datasheet.pdf

BOS-P00090-safety-datasheet.pdf