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Anti-Phospho-Elk-1 (Ser383) Antibody

Anti-Phospho-Elk-1 (Ser383) Antibody

ArtNr	BOS-P01426
Hersteller	Boster
Menge	100 ul
Kategorie	Neuroscience Neural Lineage Markers Antibodies Immunohistochemistry Western Blot Primary Antibodies Neuronal Cell Markers
Typ	Antibody
Format	Liquid
Applikationen	WB
Specific against	Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ELK 1 antibody, Elk1 antibody, ELK1 member of ETS oncogene family antibody, ELK1 protein antibody, ELK1, ETS transcription factor antibody, ELK1_HUMAN antibody, ELK2 member of ETS oncogene family antibody, ETS domain containing protein Elk 1 antibody, ETS domain containing protein Elk1 antibody, ETS domain protein Elk1 antibody, ETS domain-containing protein Elk-1 antibody, ETS like gene 1 antibody, Member of ETS oncogene family antibody, Oncogene Elk1 antibody, Tyrosine kinase (ELK1) oncogene antibody
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Manufacturer - Category	Primary Antibodies
Storage Conditions	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.
Observed Molecular Weight	44888 MW
Clonality	Polyclonal
Application notes	Specific for ~46 kDa Elk-1 phosphorylated at Ser383. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide.
Application Details	WB: 1:1000
Manufacturer - Gene Name	ELK1
Gene Full Name	ETS domain-containing protein Elk-1
Background	Elk-1 is a transcription factor involved in mediating gene transcription in response to growth factors (Hill and Treisman, 1995). Elk-1 is thought to be phosphorylated by MAP kinase at Ser-383 and phosphorylation at this site is essential for the transcriptional activity of Elk-1 (Li et al., 2003). Phosphorylation of Elk-1 has also been implicated in synaptic plasticity in the adult hippocampus (Thiels et al., 2002).
Immunogen	Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser383 of human Elk-1, conjugated to keyhole limpet hemocyanin (KLH). Immunogen species is Human.
Contents	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Purification	Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Phospho Site	Phosphorylated, Ser383
Manufacturer - Research Category	Cancer, 2339, Epigenetics and Nuclear Signaling, MAPK Pathway, Oncoproteins, Oncoproteins/Suppressors, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Transcription, Transcription Factors
Protein Name	ETS domain-containing protein Elk-1
Protein Function	Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).
Subcellular Localization	Nucleus.
Short Description	Boster Bio Anti-Phospho-Elk-1 (Ser383) Antibody (Catalog # P01426). Tested in WB applications. This antibody reacts with Mouse, Rat.
Description	Boster Bio Anti-Phospho-Elk-1 (Ser383) Antibody (Catalog # P01426). Tested in WB applications. This antibody reacts with Mouse, Rat.
Tissue Specificity	Lung and testis.
Predicted Reactivity	Canine, Human, Primate, Zebrafish

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