« Zurück
Startseite /
Anti-Phospho-AMPA Receptor (GluR 1) (Ser845) GRIA1 Rabbit Monoclonal Antibody, Clone#RM296

Anti-Phospho-AMPA Receptor (GluR 1) (Ser845) GRIA1 Rabbit Monoclonal Antibody, Clone#RM296

ArtNr	BOS-P02677-2
Hersteller	Boster
Menge	100 ul
Kategorie	Food Safety Allergenes Neuroscience Molecular Targets for Neuroscience Neural Signaling Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody Monoclonal
Format	Liquid
Applikationen	WB, IHC
Clon	RM296
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Glutamate receptor 1,GluR-1,AMPA-selective glutamate receptor 1,GluR-A,GluR-K1,Glutamate receptor ionotropic,AMPA 1,GluA1,GRIA1,GLUH1,GLUR1
Lieferbar
Manufacturer - Category	Primary Antibodies, Rabbit Monoclonal Antibodies
Storage Conditions	Store at -20°C for one year. Avoid repeated freeze-thaw cycles.
Molecular Weight	101506 MW
Clonality	Monoclonal
Application Details	Immunohistochemistry (IHC): 1:500-1:1000 dilution WB: 1:1000-1:2000 dilution.
Gene Name	GRIA1
Gene Full Name	Glutamate receptor 1
Manufacturer - Specificity	Reacts to human GluR1 AMPA Receptor only when phosphorylated at Ser845. No cross-reactivity to GluR1 that is not phosphorylated at Ser845. May also react to mouse or rat Phospho-AMPA Receptor (GluR1) (Ser845) as predicted by immunogen homology.
Immunogen	A phospho-peptide corresponding to human Phospho-Glutamate Receptor 1 (GluR1) (Ser845)
Contents	50% Glycerol/PBS with 1% BSA and 0.09% sodium azide
Purification	Protein A affinity purified from an animal origin-free culture supernatant
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Manufacturer - Research Category	Ligand-Gated Ion Channels, Neuroscience, Neurotransmission, Receptors / Channels
Protein Function	Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Subcellular Localization	Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density; Multi-pass membrane protein. Cell projection, dendrite. Cell projection, dendritic spine. Early endosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (By similarity).
Description	Boster Bio Anti-Phospho-AMPA Receptor (GluR 1) (Ser845) GRIA1 Rabbit Monoclonal Antibody, Clone#RM296 (Catalog # P02677-2). Tested in IHC, WB applications. This antibody reacts with Human.
Tissue Specificity	Widely expressed in brain.
Predicted Reactivity	Mouse, Rat
Manufacturer - Cross Reactivity	Reacts to human GluR1 AMPA Receptor only when phosphorylated at Ser845. No cross-reactivity to GluR1 that is not phosphorylated at Ser845. May also react to mouse or rat Phospho-AMPA Receptor (GluR1) (Ser845) as predicted by immunogen homology.

Hinweis: Die dargestellten Informationen und Dokumente (Bedienungsanleitung, Produktdatenblatt, Sicherheitsdatenblatt und Analysezertifikat) entsprechen unserem letzten Update und sollten lediglich der Orientierung dienen. Wir übernehmen keine Garantie für die Aktualität. Für spezifische Anforderungen bitten wir Sie, uns eine Anfrage zu stellen.

Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Arbeitsanleitung (Data Sheet) anfordern

BOS-P02677-2-datasheet.pdf

BOS-P02677-2-safety-datasheet.pdf