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Anti-Phospho-Munc-18 (Ser513) STXBP2 Antibody

Anti-Phospho-Munc-18 (Ser513) STXBP2 Antibody

ArtNr	BOS-P04909
Hersteller	Boster
Menge	100 ul
Kategorie	Neuroscience Neural Signaling Antibodies Immunohistochemistry Western Blot Primary Antibodies
Typ	Antibody
Format	Liquid
Applikationen	WB, ICC
Specific against	Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	FLJ37475 antibody, Munc 18 1 antibody, Munc 18a antibody, MUNC18 1 antibody, N-Sec1 antibody, Neuronal SEC1 antibody, NSec1 antibody, p67 antibody, Protein unc-18 homolog 1 antibody, Protein unc-18 homolog A antibody, Rb sec1 antibody, RBSEC1 antibody, STXB1_HUMAN antibody, STXBP1 antibody, Syntaxin binding protein 1 antibody, Syntaxin-binding protein 1 antibody, Unc 18 homolog antibody, Unc 18A antibody, Unc-18A antibody, Unc18 1 antibody, UNC18 antibody, Unc18-1 antibody
Lieferbar
Manufacturer - Category	Primary Antibodies
Storage Conditions	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.
Observed Molecular Weight	66453 MW
Clonality	Polyclonal
Application notes	Specific for endogenous levels of the ~65 kDa Munc-18 protein phosphorylated at Ser513. Immunolabeling is blocked by preadsorption with the phosphopeptide used as antigen, but not by the corresponding non-phosphopeptide.
Application Details	WB: 1:1000 ICC: 1:400
Manufacturer - Gene Name	STXBP2
Gene Full Name	Syntaxin-binding protein 2
Background	Munc-18 (mammalian homologue of Unc-18) is a protein that is thought to be involved in regulating exocytosis due, at least in part, to it ability to bind syntaxin (Ciufo et al., 2005). Munc18-1 is a neuron-specific member of the Sec1/Munc18 protein family that binds to syntaxin1A and is thought to stabilize the complex (Liu et al., 2004). The function of Unc-18 is thought to be regulated by PKC phosphorylation of Ser-515 in C. Elegans (Sassa et al., 1996). Ser-513 is the mammalian homologue of Ser-515 in C. Elegans.
Immunogen	Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser513 of rat Munc-18, conjugated to keyhole limpet hemocyanin (KLH). Immunogen species is Rat.
Contents	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Purification	Prepared from pooled rabbit serum by affinity purification via sequential chromatography on phospho and non-phosphopeptide affinity columns.
Concentration	0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Phospho Site	Phosphorylated, Ser513
Manufacturer - Research Category	Protein Trafficking, Signal Transduction, Vesicle Transport
Protein Name	Syntaxin-binding protein 2
Protein Function	Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N- ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.
Short Description	Boster Bio Anti-Phospho-Munc-18 (Ser513) STXBP2 Antibody (Catalog # P04909). Tested in WB, ICC applications. This antibody reacts with Rat.
Description	Boster Bio Anti-Phospho-Munc-18 (Ser513) STXBP2 Antibody (Catalog # P04909). Tested in WB, ICC applications. This antibody reacts with Rat.
Tissue Specificity	Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.
Predicted Reactivity	Bovine, Canine, Chicken, Human, Mouse, Primate, Xenopus

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