Anti-Phospho-mGluR7 (Ser862) Antibody

Primary Antibodies

102232 MW

Specific for the ~102 kDa mGluR7 protein phosphorylated at Ser862. Immunolabeling is blocked by preadsorption of antibody with the phospho-peptide used as antigen but not by the corresponding dephosphopeptide.

GRM7

Metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). The mGluRs are divided into three groups based on sequence identity and pharmacological properties: group I (mGluR1 and mGluR5) are localized in the perisynaptic region of the postsynaptic membrane, whereas group II (mGlur2 and mGluR3) and group III (mGluR4, 6, 7 and 8) are localized predominantly at presynaptic terminals. PKC phosphorylation of Ser-862 on mGluR7 has been shown to be critical for stabilizing receptor surface expression and promoting binding to the synaptic PDZ-domain-containing protein PICK1 (Suh et al., 2008).

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Metabotropic glutamate receptor 7

Cell membrane; Multi-pass membrane protein.

Boster Bio Anti-Phospho-mGluR7 (Ser862) Antibody (Catalog # P05202). Tested in WB applications. This antibody reacts with Mouse, Rat.

Bovine, Canine, Human, Primate, Zebrafish