Anti-Phospho-Protein Tyrosine Phosphatase H1 (PTPH1)(Ser459) Antibody

Primary Antibodies

103990 MW

Specific for endogenous levels of the ~104 kDa PTPH1 protein phosphorylated at Ser459. The immunolabeling is completely eliminated by treatment with ?-phosphatase.

PTPH1

Protein-tyrosine Phosphatase H1 (PTPH1) has recently been identified as a specific p38? MAPK phosphatase which is mediated through PDZ interaction (Hou et al., 2010). Ras has been demonstrated to increase both p38? and PTPH1 protein expression, and there is a coupling of increased p38? and PTPH1 protein expression in primary colon cancer tissues (Hou et al., 2010). Phosphorylation of PTPH1 at Ser-459 leads to PTPH1 stabilization, which plays an important role in Ras oncogenesis and stress response (Hou et al., 2012). Additionally, phosphorylation of PTPH1 Ser-459 reveals a novel mechanism by which MAPK signals through PTPH1 to regulate cellular response (Hou et al., 2012).

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Protein Phosphorylation, Signal Transduction, Tyrosine Phosphatases

May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

Boster Bio Anti-Phospho-Protein Tyrosine Phosphatase H1 (PTPH1)(Ser459) Antibody (Catalog # P06227). Tested in WB applications. This antibody reacts with Human, Mouse.

Bovine, Canine, Primate, Sheep