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Anti-Annexin A1/ANXA1 Antibody Picoband® Europäischer Partner

ArtNr BOS-PA1006
Hersteller Boster
Menge 100 ug/vial
Kategorie
Typ Antibody Polyclonal
Format Lyophilized
Applikationen WB, FC, IF, IHC, ICC
Specific against Human (Homo sapiens), Monkey (Cynomolgus, Simian)
Host Rabbit
Isotype IgG
Sensitivity <10pg/ml
Citations 1. Wallner, B. P.; Mattaliano, R. J.; Hession, C.; Cate, R. L.; Tizard, R.; Sinclair, L. K.; Foeller, C.; Chow, E. P.; Browning, J. L.; Ramachandran, K. L.; Pepinsky, R. B. : Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity. Nature 320: 77-81, 1986. .
2. Kovacic RT, Tizard R, Cate RL, Frey AZ, Wallner BP. Correlation of gene and protein structure of rat and human lipocortin I. Biochemistry. 1991 Sep 17;30(37):9015-21.
3. Walther, A.; Riehemann, K.; Gerke, V. A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Molec. Cell 5: 831-840, 2000.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Annexin A1;Annexin I;Annexin-1;Calpactin II;Calpactin-2;Chromobindin-9;Lipocortin I;Phospholipase A2 inhibitory protein;p35;ANXA1;ANX1, LPC1;
Similar products Annexin 1 antibody, Annexin A1 antibody, Annexin I(lipocortin I) antibody, Annexin I antibody, Annexin-1 antibody, AnnexinA1 antibody, AnnexinI antibody, ANX 1 antibody, ANX A1 antibody, ANX1 antibody, ANXA 1 antibody, ANXA1 antibody, ANXA1 protein antibody, ANXA1_HUMAN antibody, Calpactin 2 antibody, Calpactin II antibody, Calpactin-2 antibody, CalpactinII antibody, Chromobindin 9 antibody, Chromobindin-9 antibody, Chromobindin9 antibody, HGNC:533 antibody, Lipocortin 1 antibody, Lipocortin I antibody, Lipocortin1 antibody, LipocortinI antibody, LPC 1 antibody, LPC1 antibody, p35 antibody, Phospholipase A2 inhibitory protein antibody
Lieferbar
Manufacturer - Category
Primary Antibodies
Manufacturer - Isotype
Rabbit IgG
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
39 kDa
Calculated Molecular weight
38714 MW
Clonality
Polyclonal
Application Details
Western blot, 0.1-0.5?g/ml, Human, Monkey

Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml, Human, By Heat

Immunocytochemistry/Immunofluorescence, 5?g/ml, Human

Flow Cytometry (Fixed), 1-3?g/1x106 cells, Human
Manufacturer - Gene Name
ANXA1
Gene Full Name
Annexin A1
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
Annexin I, also known as lipocortin I (Lipo1), belongs to the family of annexins. These proteins are though to control the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes. In two lipocortins (I and II) a short amino-terminal sequence distinct from the core structure has potential regulatory functions which are dependent on its phosphorylation state. The gene in the mouse encodes a protein of 346 amino acid residues. Mouse Lipo1 gene spans about 17 kb and is divided into 13 exons. Annexin I gene, mapped to 9q11-q22, is located on mouse chromosome 19. Annexin I acts through the formyl peptide receptor on human neutrophils. Peptides derived from the unique N-terminal domain of annexin I serve as FPR ligands and trigger different signaling pathways in a dose-dependent manner.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human Annexin A1.
Contents
Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category
Calcium Signaling, Cell Adhesion, Cytoskeleton/ECM, Lipid Signaling, Signal Transduction, Signaling Pathway
Protein Name
Annexin A1
Protein Function
Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.
Subcellular Localization
Nucleus. Cytoplasm. Cell projection, cilium. Basolateral cell membrane. Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium. Found in the cytoplasm of type II pneumocytes and alveolar macrophages.
Description
Boster Bio Anti-Annexin A1/ANXA1 Antibody catalog # PA1006. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Monkey.
Tissue Specificity
Widely expressed, with highest expression in brain.
Sequence Similarities
Belongs to the annexin family.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug/vial
Lieferbar: In stock
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