Anti-SOCS1 Antibody Picoband®

ArtNr	BOS-PA1074
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Oncology Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Neural Transcription Factors Antibodies By Cell Type Carcinoma Obesity Immunohistochemistry Western Blot Enzymes Fatty Acid Synthesis Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Sensitivity	<1pg/ml
Citations	1. Ohya K, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H.SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase. J Biol Chem. 1997 Oct 24; 272(43):27178-82. 2. Kramer JA, Adams MD, Singh GB, Doggett NA, Krawetz SA.A matrix associated region localizes the human SOCS-1 gene to chromosome 16p13.13. Somat Cell Mol Genet. 1998 Mar; 24(2):131-3. 3. Nagai H, Naka T, Terada Y, Komazaki T, Yabe A, Jin E, Kawanami O, Kishimoto T, Konishi N, Nakamura M, Kobayashi Y, Emi M.Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas. J Hum Genet. 2003; 48(2):65-9. 4. Yoshida T, Ogata H, Kamio M, Joo A, Shiraishi H, Tokunaga Y, Sata M, Nagai H, Yoshimura A.SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis. J Exp Med. 2004 Jun 21; 199(12):1701-7.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Suppressor of cytokine signaling 1;SOCS-1;JAK-binding protein;JAB;STAT-induced STAT inhibitor 1;SSI-1;Tec-interacting protein 3;TIP-3;SOCS1;SSI1, TIP3;
Similar products	CISH 1 antibody, CISH1 antibody, Cytokine Inducible SH2 Protein 1 antibody, JAB antibody, JAK Binding Protein antibody, JAK-binding protein antibody, Janus kinase binding protein antibody, SOCS 1 antibody, SOCS-1 antibody, Socs1 antibody, SOCS1_HUMAN antibody, SSI 1 antibody, SSI-1 antibody, SSI1 antibody, STAT Induced STAT Inhibitor 1 antibody, STAT-induced STAT inhibitor 1 antibody, Suppressor of cytokine signaling 1 antibody, Supressor of cytokine Signalling 1 antibody, TEC Interacting Protein 3 antibody, Tec-interacting protein 3 antibody, TIP 3 antibody, TIP-3 antibody, TIP3 antibody
Lieferbar
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	62-65 kDa
Calculated Molecular weight	23551 MW
Clonality	Polyclonal
Application Details	Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml, Human, Mouse, Rat, By Heat Western blot, 0.1-0.5?g/ml, Human, Rat, Mouse
Manufacturer - Gene Name	SOCS1
Gene Full Name	Suppressor of cytokine signaling 1
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Suppressor of cytokine signaling 1 (SOCS1), also known as Jak-binding protein (JAB), is a negative regulator to a subset of protein-tyrosine kinases. This 211-amino acid protein has a molecular mass of about 23.5 kD. The TEC-binding region of SOCS1 resides in the N terminus. SOCS1 associates with Tec and suppresses its kinase activity. The SOCS1 gene is intronless and is mapped to on chromosome 16p13.13. SOCS1 regulates the JAK/STAT signal-transduction pathway. Moreover, it contributes to protection against hepatic injury and fibrosis, and may also protect against hepatocarcinogenesis.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human SOCS1, identical to the related mouse and rat sequences.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Adapters, Autoimmune, Cytoplasmic, Epigenetics and Nuclear Signaling, Immune System Diseases, Immunology, Nuclear Signaling Pathways, Signal Transduction
Protein Name	Suppressor of cytokine signaling 1(SOCS-1)
Protein Function	SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Subcellular Localization	Nucleus. Cytoplasmic vesicle. Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
Description	Boster Bio Anti-SOCS1 Antibody catalog # PA1074. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
Sequence Similarities	Contains 1 SH2 domain.

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