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Anti-Superoxide Dismutase 1/SOD1 Antibody Picoband® Europäischer Partner

ArtNr BOS-PA1345
Hersteller Boster
Menge 100 ug/vial
Kategorie
Typ Antibody Polyclonal
Format Lyophilized
Applikationen WB, IHC, ICC
Specific against Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host Rabbit
Isotype IgG
Sensitivity <10pg/ml
Citations 1. Crapo, J. D., Oury, T., Rabouille, C., Slot, J. W., Chang, L.-Y. Copper,zinc superoxide dismutase is primarily a cytosolic protein in human cells. Proc. Nat. Acad. Sci. 89: 10405-10409, 1992.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Superoxide dismutase [Cu-Zn];1.15.1.1;Superoxide dismutase 1;hSod1;SOD1;
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Manufacturer - Category
Primary Antibodies
Manufacturer - Isotype
Rabbit IgG
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
18 kDa
Calculated Molecular weight
15936 MW
Clonality
Polyclonal
Application Details
Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml, Human, Mouse, Rat, By Heat

Immunocytochemistry , 0.5-1?g/ml, Human, Mouse, Rat
Immunohistochemistry (Frozen Section), 0.5-1?g/ml, Mouse, Rat, Human
Western blot, 0.1-0.5?g/ml, Human, Mouse, Rat
Manufacturer - Gene Name
SOD1
Gene Full Name
Superoxide dismutase [Cu-Zn]
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
Superoxide dismutases (SOD) are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. As such, they are an important antioxidant defense in nearly all cells exposed to oxygen. One of the exceedingly rare exceptions is Lactobacillus plantarum and related lactobacilli, which use a different mechanism.Cu, Zn-SOD was found widely distributed in the cell cytosol and in the cell nucleus, consistent with it being a soluble cytosolic protein. Mitochondria and secretory compartments did not label for this protein. In human cells, peroxisomes showed a labeling density slightly less than that of cytoplasm.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of Human SOD1, different from the mouse sequence by two amino acids.
Contents
Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category
Cancer, Cancer Metabolism, Cell Biology, Chaperones, Heat Shock Proteins, Metabolism, Oxidative Stress, Pathways and Processes, Protein Trafficking, Redox Metabolism, Signal Transduction
Protein Name
Superoxide dismutase[Cu-Zn]
Protein Function
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Subcellular Localization
Cytoplasm. Nucleus. Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.
Description
Boster Bio Anti-Superoxide Dismutase 1/SOD1 Antibody catalog # PA1345. Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity
Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain.
Sequence Similarities
Belongs to the Cu-Zn superoxide dismutase family.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug/vial
Lieferbar: In stock
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