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Anti-RANK/TNFRSF11A Antibody Picoband® Europäischer Partner

ArtNr BOS-PA1382
Hersteller Boster
Menge 100 ug/vial
Quantity options 100 ug/vial 10 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug 100 ug
Kategorie
Typ Antibody Polyclonal
Format Lyophilized
Applikationen WB, IHC
Specific against Human (Homo sapiens)
Host Rabbit
Isotype IgG
Sensitivity <10 pg/ml
Sequence Contains 4 TNFR-Cys repeats.
Citations 1. Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ (1999). Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr. Rev. 20 (3): 345–57.
2. Wong BR, Josien R, Choi Y (1999). TRANCE is a TNF family member that regulates dendritic cell and osteoclast function. J. Leukoc. Biol. 65 (6): 715–24.
3. Theill LE, Boyle WJ, Penninger JM (2002). RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu. Rev. Immunol. 20: 795–823.
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias Tumor necrosis factor receptor superfamily member 11A,Osteoclast differentiation factor receptor,ODFR,Receptor activator of NF-KB,CD265,TNFRSF11A,RANK
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Manufacturer - Category
Primary Antibodies
Storage Conditions
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular weight
90 kDa
Calculated Molecular weight
66034 MW
Clonality
Polyclonal
Application Details
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human
Western blot, 0.1-0.5μg/ml, Human
Gene Name
TNFRSF11A
Gene Full Name
Tumor necrosis factor receptor superfamily member 11A
Manufacturer - Specificity
No cross reactivity with other proteins.
Background
Receptor Activator of Nuclear Factor K B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling. RANKL (Receptor Activator for Nuclear Factor K B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al. (1997) mapped the RANK gene to 18q22.1.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human RANK.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Purification
Immunogen affinity purified.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Concentration
Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Manufacturer - Research Category
Adapters, Atherosclerosis, Cardiovascular, Cytokines, Cytoskeleton/ECM, Extracellular Matrix, Growth Factors/Hormones, Immunology, Innate Immunity, Signal Transduction, Structures, TNF Superfamily, Transmembrane, Vascular Inflammation
Protein Name
Tumor necrosis factor receptor superfamily member 11A
Protein Function
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
Subcellular Localization
Isoform 1: Cell membrane; Single-pass type I membrane protein.
Description
Boster Bio Anti-RANK/TNFRSF11A Antibody catalog # PA1382. Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Tissue Specificity
Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.
Sequence Similarities
Contains 4 TNFR-Cys repeats.
Manufacturer - Cross Reactivity
No cross-reactivity with other proteins

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug/vial
Lieferbar: In stock
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