Anti-HSD17B6 Antibody Picoband®

ArtNr	BOS-PA1386
Hersteller	Boster
Menge	100 ug/vial
Kategorie	Oncology Food Safety Hormones Metabolism Diabetes Antibodies Immunohistochemistry Western Blot Primary Antibodies By Organ Lung Cancer
Typ	Antibody Polyclonal
Format	Lyophilized
Applikationen	WB, IHC
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Sensitivity	<10pg/ml
Citations	1. Baker ME (Feb 2001). "Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action". Mol Cell Endocrinol 171 (1-2): 211–5. doi:10.1016/S0303-7207(00)00414-7. PMID 11165032. 2. Biswas, M. G., Russell, D. W. Expression cloning and characterization of oxidative 17-beta- and 3-alpha –hydroxysteroid dehydrogenases from rat and human prostate. J. Biol. Chem. 272: 15959-15966, 1997.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	17-beta-hydroxysteroid dehydrogenase type 6;17-beta-HSD 6;17-beta-HSD6;1.1.1.105;1.1.1.239;1.1.1.62;3-alpha->beta-hydroxysteroid epimerase;3-alpha->beta-HSE;Oxidative 3-alpha hydroxysteroid dehydrogenase;Short chain dehydrogenase/reductase family 9C member 6;HSD17B6;RODH, SDR9C6;
Similar products	Short chain dehydrogenase/reductase family 9C, member 6 antibody, 17-beta-HSD 6 antibody, 17-beta-HSD6 antibody, 17-beta-hydroxysteroid dehydrogenase type 6 antibody, 3 hydroxysteroid epimerase antibody, 3(alpha>beta) hydroxysteroid epimerase antibody, 3(alpha>beta) hydroxysteroid epimerasel antibody, 3-alpha->beta-HSE antibody, 3-alpha->beta-hydroxysteroid epimerase antibody, H17B6_HUMAN antibody, HSD17B6 antibody, HSE antibody, Hydroxysteroid(17 beta) dehydrogenase 6 antibody, Hydroxysteroid(17 beta) dehydrogenase 6 homolog(mouse) antibody, Hydroxysteroid 17 beta dehydrogenase 6 antibody, NAD+ dependent 3 alpha hydroxysteroid dehydrogenase 3 hydroxysteroid epimerase antibody, NAD+ dependent 3 alpha hydroxysteroid dehydrogenase antibody, Oxidative 3 alpha hydroxysteroid dehydrogenase antibody, Oxidative 3-alpha hydroxysteroid dehydrogenase antibody, Oxidoreductase antibody, Retinol dehydrogenase antibody, RODH antibody, SDR9C6 antibody
Lieferbar
Specificity	No cross reactivity with other proteins.
Manufacturer - Category	Primary Antibodies
Manufacturer - Isotype	Rabbit IgG
Storage Conditions	Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight	35 kDa
Calculated Molecular weight	35966 MW
Clonality	Polyclonal
Application Details	Immunohistochemistry (Paraffin-embedded Section), 0.5-1?g/ml, Human, By Heat Western blot, 0.1-0.5?g/ml, Human
Manufacturer - Gene Name	HSD17B6
Gene Full Name	17-beta-hydroxysteroid dehydrogenase type 6
Manufacturer - Specificity	No cross reactivity with other proteins.
Background	Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene. The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. Baker ME et al point out expression of 17beta-HSDs had an important role in the early evolution of the physiological response to androgens and estrogens. Biswas and Russell concluded that 17beta-HSD6 and RoDH play opposing roles in androgen action; 17beta-HSD6 inactivates 3alpha-adiol by conversion to androsterone and RoDH activates 3alpha-adiol by conversion to dihydrotestosterone. The synthesis of an active steroid hormone by back conversion of an inactive metabolite represents a potentially important mechanism by which the steady state level of a transcriptional effector can be regulated.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human HSD17B6.
Contents	Each vial contains 5 mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg NaN3.
Purification	Immunogen affinity purified.
Reconstitution	Add 0.2 ml of distilled water will yield a concentration of 500 ug/ml.
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 ?g/ml.
Manufacturer - Research Category	Growth Factors/Hormones, Signal Transduction
Protein Name	17-beta-hydroxysteroid dehydrogenase type 6(17-beta-HSD 6/17-beta-HSD6)
Protein Function	NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha, 17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha- androstane-3, 17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids.
Subcellular Localization	Microsome membrane; Peripheral membrane protein; Lumenal side. Early endosome membrane; Peripheral membrane protein; Lumenal side.
Description	Boster Bio Anti-HSD17B6 Antibody catalog # PA1386. Tested in IHC, WB applications. This antibody reacts with Human.
Tissue Specificity	Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain.
Sequence Similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

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