Hersteller |
Boster
|
Kategorie |
|
Typ |
Elisa-Kit |
Specific against |
Human |
Applikationen |
ELISA |
Menge |
96 wells/kit, with removable strips. |
ArtNr |
BOS-EK0920 |
Targets |
TNFRSF25, TNFRSF1A, TNFSF12, TNF |
eClass 6.1 |
32160605 |
eClass 9.0 |
32160605 |
Lieferbar |
|
Manufacturers Product Category |
PicoKine® ELISA Kits |
Manufacturers Research Category |
Apoptosis, Cancer, Cell Biology, Cell Death, Growth Factors, Invasion/Microenvironment |
Short Description |
Human TNFSF12/Tweak ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFSF12 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml. |
Description |
Human TNFSF12/Tweak ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFSF12 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml. |
Background |
Tumor necrosis factor ligand superfamily member 12 also known as TNF-related weak inducer of apoptosis (TWEAK) is a protein that in humans is encoded by the TNFSF12 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator ofangiogenesis. The TNFSF12 gene lies 878 bp upstream of the putative transcriptional start site of the TNFSF13 gene on chromosome 17p13.1. |
Gene Name |
TNFSF12 |
Application Details |
Dilution ratio of 1:1, concentration in serum and plasma is 200-1300 pg/ml. |
Immunogen |
Expression system for standard: E.coli; Immunogen sequence: S94-H249 |
Cross-reactivity |
There is no detectable cross-reactivity with other relevant proteins. |
Sample Type |
cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). |
Capture antibody|Detection antibody |
monoclonal antibody from mouse|polyclonal antibody from goat |
Storage |
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.) |
Anticoagulant |
heparin or EDTA |
Gene Full Name |
Tumor necrosis factor ligand superfamily member 12 |
Molecular Weight |
27216 MW |
Protein Function |
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.. |
Subcellular Localization |
Cell membrane ; Single-pass type II membrane protein. |
Tissue Specificity |
Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain. |
Protein Name |
Tumor necrosis factor ligand superfamily member 12 |
Sequence Similarities |
Belongs to the tumor necrosis factor family. |
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