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Human TNFSF12/Tweak ELISA Kit PicoKine®

Human TNFSF12/Tweak ELISA Kit PicoKine®

Manufacturer	Boster
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes By Cell Type Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis ELISA Cardiovascular Research Ischemia & Reperfusion Injury ELISA & Immunoassays ELISA Kits Immunoassay By Organ Bone Cancer
Type	Elisa-Kit
Specific against	Human
Applications	ELISA
Amount	96 wells/kit, with removable strips.
Item no.	BOS-EK0920
Targets	TNFRSF25, TNFRSF1A, TNFSF12, TNF
eClass 6.1	32160605
eClass 9.0	32160605
Available
Manufacturers Product Category	PicoKine® ELISA Kits
Manufacturers Research Category	Apoptosis, Cancer, Cell Biology, Cell Death, Growth Factors, Invasion/Microenvironment
Short Description	Human TNFSF12/Tweak ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFSF12 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.
Description	Human TNFSF12/Tweak ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFSF12 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.
Background	Tumor necrosis factor ligand superfamily member 12 also known as TNF-related weak inducer of apoptosis (TWEAK) is a protein that in humans is encoded by the TNFSF12 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator ofangiogenesis. The TNFSF12 gene lies 878 bp upstream of the putative transcriptional start site of the TNFSF13 gene on chromosome 17p13.1.
Gene Name	TNFSF12
Application Details	Dilution ratio of 1:1, concentration in serum and plasma is 200-1300 pg/ml.
Immunogen	Expression system for standard: E.coli; Immunogen sequence: S94-H249
Cross-reactivity	There is no detectable cross-reactivity with other relevant proteins.
Sample Type	cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA).
Capture antibody\|Detection antibody	monoclonal antibody from mouse\|polyclonal antibody from goat
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant	heparin or EDTA
Gene Full Name	Tumor necrosis factor ligand superfamily member 12
Molecular Weight	27216 MW
Protein Function	Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion..
Subcellular Localization	Cell membrane ; Single-pass type II membrane protein.
Tissue Specificity	Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
Protein Name	Tumor necrosis factor ligand superfamily member 12
Sequence Similarities	Belongs to the tumor necrosis factor family.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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