Hersteller |
Boster
|
Kategorie |
|
Typ |
Elisa-Kit |
Specific against |
Human |
Applikationen |
ELISA |
Menge |
For 5 plates, 96 wells each |
ArtNr |
BOS-EZ0702 |
Targets |
CD40 |
eClass 6.1 |
32160605 |
eClass 9.0 |
32160605 |
Lieferbar |
|
Manufacturers Product Category |
EZ-Set™ ELISA Kits (Ab Pairs) |
Manufacturers Research Category |
Lymphoid, Myeloid, Stem Cells, Vascular Inflammation |
Short Description |
Human CD40/TNFRSF5 ELISA Kit EZ-Set™ (DIY Antibody Pairs) (antibody pairs and standards for assay development). Quantitate Human CD40 in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk. |
Description |
Human CD40/TNFRSF5 ELISA Kit EZ-Set™ (DIY Antibody Pairs) (antibody pairs and standards for assay development). Quantitate Human CD40 in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk. |
Background |
CD40 is a cell surface receptor that is expressed on the surface of all mature B cells, most mature B-cell malignancies, and some early B-cell acute lymphocytic leukemias, but is not expressed on plasma cells. The CD40 gene is localized to the long arm of chromosome 20, bands q12-q13.2. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. |
Gene Name |
CD40 |
Immunogen |
Expression system for standard: NS0; Immunogen sequence: E21-R193 |
Cross-reactivity |
There is no detectable cross-reactivity with other relevant proteins. |
Sample Type |
cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk. |
Storage |
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.) |
Anticoagulant |
heparin or EDTA |
Gene Full Name |
Tumor necrosis factor receptor superfamily member 5 |
Molecular Weight |
30619 MW |
Protein Function |
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion. |
Subcellular Localization |
Isoform I: Cell membrane; Single-pass type I membrane protein. |
Tissue Specificity |
B-cells and in primary carcinomas. |
Protein Name |
Tumor necrosis factor receptor superfamily member 5 |
Sequence Similarities |
Contains 4 TNFR-Cys repeats. |
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