Hersteller |
Boster
|
Kategorie |
|
Typ |
Elisa-Kit |
Specific against |
Mouse |
Applikationen |
ELISA |
Menge |
96 wells/kit, with removable strips. |
ArtNr |
BOS-EK0495 |
Targets |
PDGFB, CCL5 |
eClass 6.1 |
32160605 |
eClass 9.0 |
32160605 |
Lieferbar |
|
Manufacturers Product Category |
PicoKine® ELISA Kits |
Manufacturers Research Category |
Antiviral Signaling, Atherosclerosis, Cardiovascular, Chemokines, Immune System Diseases, Immunology, Innate Immunity, Vascular Inflammation |
Short Description |
Mouse Rantes ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Ccl5 in cell culture supernatants. serum and plasma (heparin, EDTA, citrate). Sensitivity: 1pg/ml. |
Description |
Mouse Rantes ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Ccl5 in cell culture supernatants. serum and plasma (heparin, EDTA, citrate). Sensitivity: 1pg/ml. |
Background |
Rantes (regulated on activation normal T cell expressed and secreted) is one of the natural ligands for the chemokine receptor CCR5 and potently suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Peripheral blood mononuclear cells or CD4 (+) lymphocytes obtained from different individuals have wide variations in their ability to secrete RANTES. The Rantes gene product is predicted to be 10 kDa and, after cleavage of the signal peptide, approximately 8 kDa. Of the 68 residues, 4 are cysteines, and there are no sites for N-linked glycosylation. Rantes is expressed by cultured T cell lines that are Ag specific and growth factor dependent. |
Gene Name |
CCL5 |
Application Details |
Dilution ratio of 1:1, concentration in serum and plasma is 56-192 pg/ml. |
Immunogen |
Expression system for standard: E.coli; Immunogen sequence: S24-S91 |
Cross-reactivity |
There is no detectable cross-reactivity with other relevant proteins. |
Sample Type |
cell culture supernatants. serum and plasma (heparin, EDTA, citrate). |
Capture antibody|Detection antibody |
monoclonal antibody from rat|polyclonal antibody from goat |
Storage |
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.) |
Anticoagulant |
heparin, EDTA or citrate |
Gene Full Name |
C-C motif chemokine 5 |
Molecular Weight |
10071 MW |
Protein Function |
Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells.. |
Subcellular Localization |
Secreted. |
Tissue Specificity |
T-cell and macrophage specific. |
Protein Name |
C-C motif chemokine 5 |
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