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Mouse Rantes ELISA Kit PicoKine®

Mouse Rantes ELISA Kit PicoKine®

Manufacturer	Boster
Category	Oncology Food Safety Histamines Neuroscience Neuroinflammation Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite By Cell Type Blastoma Carcinoma Glioma Sarcoma ELISA ELISA & Immunoassays ELISA Kits Immunoassay By Organ Pancreatic Cancer
Type	Elisa-Kit
Specific against	Mouse
Applications	ELISA
Amount	96 wells/kit, with removable strips.
Item no.	BOS-EK0495
Targets	PDGFB, CCL5
eClass 6.1	32160605
eClass 9.0	32160605
Available
Manufacturers Product Category	PicoKine® ELISA Kits
Manufacturers Research Category	Antiviral Signaling, Atherosclerosis, Cardiovascular, Chemokines, Immune System Diseases, Immunology, Innate Immunity, Vascular Inflammation
Short Description	Mouse Rantes ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Ccl5 in cell culture supernatants. serum and plasma (heparin, EDTA, citrate). Sensitivity: 1pg/ml.
Description	Mouse Rantes ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Ccl5 in cell culture supernatants. serum and plasma (heparin, EDTA, citrate). Sensitivity: 1pg/ml.
Background	Rantes (regulated on activation normal T cell expressed and secreted) is one of the natural ligands for the chemokine receptor CCR5 and potently suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Peripheral blood mononuclear cells or CD4 (+) lymphocytes obtained from different individuals have wide variations in their ability to secrete RANTES. The Rantes gene product is predicted to be 10 kDa and, after cleavage of the signal peptide, approximately 8 kDa. Of the 68 residues, 4 are cysteines, and there are no sites for N-linked glycosylation. Rantes is expressed by cultured T cell lines that are Ag specific and growth factor dependent.
Gene Name	CCL5
Application Details	Dilution ratio of 1:1, concentration in serum and plasma is 56-192 pg/ml.
Immunogen	Expression system for standard: E.coli; Immunogen sequence: S24-S91
Cross-reactivity	There is no detectable cross-reactivity with other relevant proteins.
Sample Type	cell culture supernatants. serum and plasma (heparin, EDTA, citrate).
Capture antibody\|Detection antibody	monoclonal antibody from rat\|polyclonal antibody from goat
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant	heparin, EDTA or citrate
Gene Full Name	C-C motif chemokine 5
Molecular Weight	10071 MW
Protein Function	Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells..
Subcellular Localization	Secreted.
Tissue Specificity	T-cell and macrophage specific.
Protein Name	C-C motif chemokine 5

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