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DKK1 Hi-5 Dickkopf-Related Protein 1 Human Recombinant Protein

DKK1 Hi-5 Dickkopf-Related Protein 1 Human Recombinant Protein

Hersteller	Boster
Kategorie	Oncology By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Specific against	other
Format	Solution
Menge	5ug
ArtNr	BOS-PROTO94907
Targets	DKK1
eClass 6.1	34160400
eClass 9.0	42020190
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Contents	The DKK1 protein solution (0.25mg/ml) contains PBS (pH 7.4) and 10% Glycerol.
Description	DKK1 produced in Hi-5 is a single, glycosylated polypeptide chain containing 253 amino acids (32-266 a.a.) and having a molecular mass of 27.8 kDa (Molecular size on DSD-PAGE will appear at approximately 40kDa). DKK1 is expressed with a 15 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Gene name	DKK1
Protein function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Purification	Greater than 85.0% as determined by SDS-PAGE.
Shipping	Shipped with wet ice
Short description	DKK27.8 kDa (Molecular size on DSD-PAGE will appear at approximately 40kDa). DKK1 is expressed with a 15 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Storage	Store in -20° C for long term storage. After reconstitution, store in 4° C for short term usage within a few days. Avoid freeze-thaw cycles.
Subcellular localization	Secreted.
Tissue specificity	Placenta.
Format Information	Sterile filtered colorless solution.

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Menge: 5ug

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Lieferung vsl. bis 13.06.2024

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