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DKK1 Hi-5 Dickkopf-Related Protein 1 Human Recombinant Protein

DKK1 Hi-5 Dickkopf-Related Protein 1 Human Recombinant Protein

Manufacturer	Boster
Category	Oncology By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Specific against	other
Format	Solution
Amount	5ug
Item no.	BOS-PROTO94907
Targets	DKK1
eClass 6.1	34160400
eClass 9.0	42020190
Available
Contents	The DKK1 protein solution (0.25mg/ml) contains PBS (pH 7.4) and 10% Glycerol.
Description	DKK1 produced in Hi-5 is a single, glycosylated polypeptide chain containing 253 amino acids (32-266 a.a.) and having a molecular mass of 27.8 kDa (Molecular size on DSD-PAGE will appear at approximately 40kDa). DKK1 is expressed with a 15 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Gene name	DKK1
Protein function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
Purification	Greater than 85.0% as determined by SDS-PAGE.
Shipping	Shipped with wet ice
Short description	DKK27.8 kDa (Molecular size on DSD-PAGE will appear at approximately 40kDa). DKK1 is expressed with a 15 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Storage	Store in -20° C for long term storage. After reconstitution, store in 4° C for short term usage within a few days. Avoid freeze-thaw cycles.
Subcellular localization	Secreted.
Tissue specificity	Placenta.
Format Information	Sterile filtered colorless solution.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5ug

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Delivery expected until 5/30/2024